Immunosuppressant Drugs: Role in Periodontium

A Review on Therapeutic Drug Monitoring of Immunosuppressant Drugs

Immunosuppressants require therapeutic drug monitoring because of their narrow therapeutic index and significant inter-individual variability in blood concentrations. This variability can be because of factors like drug-nutrient interactions, drug-disease interactions, renal-insufficiency, inflammation and infection, gender, age, polymorphism and liver mass. Drug monitoring is widely practiced ...

Immunophilins: Receptor Protein For Immunosuppressant Drugs

Adherence to immunosuppressant drugs in patients with connective tissue diseases.

1 Oldberg A. COMP is structurally related to the thrombospondins. J Biol Chem 1992;267:22346–50. 2 Hedbom E, Antonsson P, Hierpe A et al. Cartilage matrix proteins. An acidic oligomeric protein (COMP) detected only in cartilage. J Biol Chem 1992;267:6132–6. 3 Saxne T, Heinegard D. Cartilage oligomeric matrix protein: a novel marker of cartilage turnover detectable in synovial fluid and blood. B...

A Review on Therapeutic Drug Monitoring of Immunosuppressant Drugs

: Immunosuppressants require therapeutic drug monitoring because of their narrow therapeutic index and significant inter-individual variability in blood concentrations. This variability can be because of factors like drug-nutrient interactions, drug-disease interactions, renal-insufficiency, inflammation and infection, gender, age, polymorphism and liver mass. Drug monitoring is widely practice...

Role of Estrogen and Progesterone in the Periodontium

The investing and supporting structures of the teeth, termed Periodontium is responsive to endogenous hormones of our body. Among the endogenous hormone Estrogen and Progesterone have direct influence on oral tissues. The periodontal status at a given time is a cumulative effect of sex hormone levels, their regulatory impact, and the effects of interventions. The two hormones act synergisticall...